Last edited by Shakaran
Thursday, August 6, 2020 | History

5 edition of Cyclic Nucleotide Phosphodiesterases found in the catalog.

Cyclic Nucleotide Phosphodiesterases

Structure, Regulation and Drug Action (Wiley Series on Molecular Pharmacology of Cell Regulation)

  • 380 Want to read
  • 37 Currently reading

Published by John Wiley & Sons .
Written in English


Edition Notes

ContributionsJoe Beavo (Editor), Miles D. Houslay (Editor)
The Physical Object
Number of Pages358
ID Numbers
Open LibraryOL7631099M
ISBN 100471927074
ISBN 109780471927075

Cyclic nucleotide phosphodiesterase (PDE) 3B plays an important role in the antilipolytic action of insulin and, thereby, the release of fatty acids from adipocytes. Increased concentrations of circulating fatty acids as a result of elevated or unrestrained lipolysis cause insulin resistance. The li . Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.

The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and ro. 3'5'-cyclic nucleotide phosphodiesterases are a family of lly, these enzymes hydrolyze some nucleoside 3',5'-cyclic phosphate to some nucleoside 5'-phosphate thus controlling the cellular levels of the cyclic second messengers and the rates of their degradation. Some examples of nucleoside 3',5'-cyclic phosphate include.

  Kelly, M. P. et al. Select 3΄,5΄-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain. Cell. Signal. 26, – (). ISBN: OCLC Number: Description: xvii, pages: illustrations. Contents: Cyclic AMP turnover in intact tissue: role of cyclic nucleotide phosphodiesterases --Use of the yeast low-Km cAMP phosphodisterase gene to control cyclic AMP levels in mammalian cells --Catalytic and regulatory properties of calmodulin-stimulated phosphodiesterases .


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Cyclic Nucleotide Phosphodiesterases Download PDF EPUB FB2

Shalender Bhasin, Rosemary Basson, in Williams Textbook of Endocrinology (Thirteenth Edition), Cyclic Nucleotide Phosphodiesterases. Cyclic nucleotide phosphodiesterases hydrolyze cAMP and cGMP, thus reducing their concentrations within the cavernosal smooth muscle.

Of the 13 or more isoforms of cyclic nucleotide phosphodiesterases that have been identified, isoforms 2, 3, 4, and 5. Given the significant role of cyclic nucleotides in signal-transduction pathways, it is not surprising that their metabolism and synthesis is highly regulated.

Such metabolism is achieved by a large number of enzymes, the phosphodiesterases (PDE), which catalyze the conversion of cAMP and cGMP into 5′-AMP and 5′-GMP, respectively, via hydrolysis of the 3′-phosphoester bonds (Fig. ).Author: Ronald S Duman, Eric J Nestler. Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms.

It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe.

Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery helps scientists understand the concepts to develop more selective and potent inhibitors and modulators as treatments for neurological diseases.

A number of expert authors from both academia and industry capture these principles by focusing on the. About this book This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications.

A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage.

Book Description. Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.

A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. Like other nucleotides, cyclic nucleotides are composed of three functional groups: a sugar, a nitrogenous base, and a single phosphate can be seen in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) images, the 'cyclic.

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field.

There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide PhosphCited by: In the last few years there has been a veritable explosion of knowledge about cyclic nucleotide phosphodiesterases.

In particular, the accumulating data showing that there are a large number of different phosphodiesterase isozymes have triggered an. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.

Beavo JA(1). Author information: (1)Department of Pharmacology, University of Washington, Seattle, USA. In the last few years there has been a veritable explosion of knowledge about cyclic nucleotide phosphodiesterases. Title: Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs VOLUME: 16 ISSUE: 9 Author(s):Therese Keravis and Claire Lugnier Affiliation:CNRS UMRUniversite de Strasbourg, laboratoire de Biophotonique et Pharmacologie Faculte de Pharmacie, 74 route du Rhin, BPIllkirch, France.

Keywords:PDEs, regulatory domain, cAMP /cGMP signaling, peptide motif. Over the last two decades there has been a growing interest in cyclic nucleotide research in plants with an emphasis on the elucidation of the roles of cGMP and cAMP.

In Cyclic Nucleotide Signaling in. Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolytic destruction of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), to produce 5’-AMP and 5’-GMP, respectively.

These second messengers are important regulators of intracellular signal transduction Cited by: In one volume, this text brings together the most up-to-date and reliable information available on the structure, function and regulation of cyclic nucleotide phosphodiesterases.

Intended for researchers and students interested in processes controlled by CAMP and CGMP, it is the only book. Modulation of the cyclic nucleotide phosphodiesterases (PDEs) superfamily is emerging as a possible therapeutic approach.

Indeed, through specific hydrolysis of cyclic AMP (cAMP) and/or cyclic GMP (cGMP), PDEs control short-term protein phosphorylation, long-term protein expression (Keravis & Lugnier, ; Maurice et al., ) and even Cited by: 2. Cyclic nucleotides exert their physiological effects by binding to four major classes of cellular receptors: cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-dependent protein kinases, cyclic GMP-regulated phosphodiesterases, cAMP-binding guanine nucleotide exchange factors, and cyclic nucleotide-regulated cation.

Buy Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery (Wiley Series in Drug Discovery and Development Book 19): Read Books Reviews - ce: $   These include the newly discovered class of cAMP-activated guanine nucleotide exchange factors (cAMP-GEF or EPAC) [2, 3], cyclic nucleotide-gated channels (CNGC), and cAMP-dependent protein kinases (PKAs), the latter being the best-characterized effectors in granulosa cells.

It is established that cAMP binds to the regulatory subunit of PKA. The cAMP signalling pathway has emerged as a key regulator of haematopoietic cell proliferation, differentiation and apoptosis. In parallel, general understanding of the biology of cyclic nucleotide PDEs (phosphodiesterases) has advanced considerably, revealing the remarkable complexity of this enzyme system that regulates the amplitude, kinetics and location of intracellular.

Indicated by a series of recent studies, cyclic nucleotide phosphodiesterases (PDEs) may represent a promising class of therapeutic targets for alcohol-related disorders. In mammalians, PDEs are the only known enzymes that catalyze the hydrolysis of the cyclic AMP (cAMP) and cyclic GMP (cGMP).Cited by: 3.

Cyclic nucleotide phosphodiesterases. [W Joseph Thompson; Samuel J Strada;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Book: All Authors / Contributors: W Joseph Thompson; Samuel J Strada.

Find more information about: ISBN: Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may contribute to the decreased apoptosis that occurs in chronic lymphocytic leukemia (CLL), we assessed the expression levels of PDE isoforms in peripheral blood mononuclear cells (PBMC) of healthy adults and patients with CLL.cyclic nucleotide phosphodiesterases, type 4 () Filter by: Remove filter: physiology () Filter by: Remove filter: 3',5'-cyclic-amp phosphodiesterases - antagonists & inhibitors () Filter by: Remove filter: 3',5'-cyclic-amp phosphodiesterases - metabolism ()